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I will describe Quokka, a new AMR code for astrophysics, aimed at problems in star formation and galaxy formation. Quokka is a Newtonian radiation hydrodynamics code with support for particles, chemistry, self-gravity, and (soon) magnetic fields based on a method-of-lines formulation. We use AMReX's unique capabilities to enable many of these physics features, from AMReX's OpenBC Poisson solver for self-gravity, to AMReX-Astro Microphysics for the cell-by-cell chemistry network integration with symbolic code generation. I will talk about our current code development focused on particles and a constrained-transport implementation of magnetohydrodynamics, and briefly mention applications in simulating galactic winds and the formation of the first stars.