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The 4C (Comprehensive Computational Community Code) multiphysics simulation framework has been developed to address complex physical phenomena across various scientific and engineering domains. From its inception, 4C has relied on the Trilinos project, an open-source software library for scalable numerical computations, as its backbone for sparse linear algebra and MPI-parallel computing. This integration enhances 4C's computational capabilities and, more importantly, allows the 4C developers to focus on their core research interest: the numerical modeling of multiphysics systems. The synergy between 4C's physics models and Trilinos' numerical solvers facilitates the simulation of coupled multiphysics systems with improved accuracy and performance. Over the years, this synergy has — in parts — evolved to a co-development of both software frameworks. This presentation will delve into the methodologies employed to incorporate Trilinos into the 4C framework, discuss software and development challenges, and showcase application case studies that demonstrate the practical benefits of this integration in simulating complex multiphysics systems such as fluid-solid interactions, contact mechanics or beam-solid interaction.